As a dermatologist, Dr. Loretta's passion is helping women feel confident as they age. Dermatologists acknowledge that more than 85% of all skin aging changes are the result of external factors—and we have mostly blamed the sun. But through pioneering clinical research for the past 40 years, Dr. Loretta has discovered that there are really four principal external factors that contribute to aging skin: pollution, light, climate and irritants. The result is loss of firmness and luminosity and increase in lines, age spots, redness and dry skin. Dr.